Colored scanning electronic micrograph of a highly swollen apoptotic (blue) mobile with SARS-COV-2 (yellow) virus particles, extracted from a patient sample.
Covid-19 doesn’t care who he infects. However, there is sufficient evidence that men, especially older men, are more vulnerable to serious infections than women.
In a new study, researchers at Yale University investigated this obvious gender-based difference and revealed a imaginable explanation for why men are more likely than women to suffer serious and fatal cases of Covid-19.
These are key differences in the immune reaction in the early stages of infection. As reported in the journal Nature this week, the small test allowed the team to compare 98 patients (average age 61 to 64 years) admitted to Yale New Haven Hospital in the United States. covid-19 cases of mild to moderate. Using nasal, saliva and blood samples taken from unidentified patients and control subjects, the team tested how the framework developed an immune reaction to the disease.
They found that women seem to produce a “more powerful and physically sustained” T-mobile reaction than male patients. T-cell phones are a type of white-blooded cell phone that serves as vital infantry of the immune system, attacking express foreign particles. Mobile reactions tend to be related to higher disease outcomes.
At the same time, it has been discovered that men produce more than one other type of mobile called cytokines, signaling molecules that recruit mobiles immune to inflammation sites. Although they are components of the immune formula, their function may be counterproductive in severe cases. Covid-19 because of what’s called a “cytokine storm. “This is when the immune formula overreacts to detect infection, releasing too many pro-inflammatory cytokines, leading to hyperinflmatation. Excessive inflammation can cause fluid to build up in the lungs, tissue damage, organ failure and a number of other problems.
In short: women tend to produce more T cells, while men tend to produce more cytokines.
The researchers say that this wisdom can also be used by physicians to tailor their remedies to other people with severe Covid-19. For example, men would possibly benefit from remedies that increase T-cell response, while women would possibly benefit from remedies that decrease early innate immune responses.
”We now have a transparent understanding that suggests that the immune landscape in PATIENTS with COVID-19 is particularly different between the sexes and that those differences would possibly underlie greater susceptibility to disease in men’,’ said Akiko Iwasaki, study leader, Professor Waldemar Von Zedtwitz in Immunobiology and Molecular Biology, from Bodega and Development, and a researcher from the Howard Hughes Medical Institute Array, he said in a statement.
“Taken together, this knowledge recommends that we want other methods to make remedies and vaccines equally effective for women and men. “
Sign up for the weekly clinical policy right in your inbox
This uses cookies
This online page uses cookies for user experience. By using our online page, you accept all cookies in accordance with our cookie policy.