For their speculation that aVNS also supports the curative procedure in severe cases of COVID-19, the researchers worked heavily with Favoriten Hospital, Medical University Vienna, Health Services Center of the Private Clinic Vienna, Sigmund Freud Private University Vienna, and Immunological Day Clinic Vienna.
aVNS in serious Corona courses
In their most recent study, the study team was able to show that there is the positive effect of vagus nerve stimulation on the course of severe coronary heart disease, already predicted in 2020, at the beginning of the pandemic. To this end, the team studied the use of AVNS in patients seriously ill with Corona and about to obtain synthetic breathing.
When the virus attacks the body, the inflammatory reaction and healing process can become unbalanced. The body’s inflammatory reaction then causes more damage than the virus itself. This balance should be restored, for example, through the use of an aVNS system. “Electrostimulation of the atrium The vagus nerve was not only able to prevent the inflammatory reaction in COVID-19 patients, but it was even able to counteract it,” says Eugenijus Kaniusas, a professor at TU Wien’s Institute of Biomedical Electronics.
Stimulating at the same time
The healing good fortune of aVNS also increases when adapting the formula. If an aVNS formula sends electrical impulses constantly, it can lead to side effects such as pain. Energy intake is also particularly higher than when the formula reacts separately to the patient and sends targeted stimuli. To achieve this, researchers from PhD student Babak Dabiri incorporated closed-loop control. Eugenijus Kaniusas explains that “this allows us to stimulate the vagus nerve precisely when the brain is listening. This is the case when the center contracts and blood flows into the vessels or when the user exhales. “In this way, overstimulation and understimulation, which are the effects of persistent AVNS, can be avoided.
While the undeniable measurements refer exclusively to the past, Kaniusas and his team worked with predictions: “In the study, we were able to show that predictive stimulation works and leads to the desired outcome. This was imaginable thanks to a formula feedback function, in which the aVNS formula can constructively interfere with the parasympathetic formula,” explains electrical engineer Kaniusas. “The aVNS formula listens to the measured biosignals and sends its stimulus at the right time, like a wise electric pill,” he, despite everything, makes a comparison. This is a vital step in the direction of personalization, through which the studio team also hopes for greater healing luck and user acceptance.
Babak Dabiri et al, Atrial vagus nerve stimulator for closed-loop biofeedback-based operation, analog integrated circuits, and signal processing (2022). DOI: 10. 1007/s10470-022-02037-8
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