Seeker
Vaccination with the bivalent vaccine against COVID-19 begins. Popularly known as “the fifth dose”, it is a new fitness strategy that – in this first stage, which runs until October 28 – is aimed at fitness officials and immunocompromised people, such as dialysis patients. , transplant patients, patients undergoing cancer treatment and autoimmune diseases receiving biological treatments.
The new pharmaceutical products developed through the Pfizer/BioNTech and Moderna laboratories, legal through the FAI for use from 12 and 18 years of age, respectively, are included in the National Vaccination Plan (PNI), while in Chile they have been reconverted to the first country in Latin America that this bivalent vaccine opposes two variants of SARS-CoV-2, the original Wuhan and Omicron, which currently predominates. On the other hand, it is most likely that, like the flu vaccine, adjustments from year to year with the new edition of the virus, the existing bivalent of its composition is the main variant of the moment at the global level.
La Dra. Vivian Luchsinger, viróloga y académica de la Facultad de Medicina de la Universidad de Chile, explica que “dado que el virus en su ciclo de replicación genera nuevas variantes constantemente, es posible que algunas de ellas tengan propiedades que les permita predominar entre las variantes circulantes y, por lo tanto, deba ser incluida en una vacuna. Aunque no es posible asegurarlo, es muy posible que la vacuna deba cambiar cada año. La base de esto es que la interacción antígeno-anticuerpo de la respuesta inmune es específica. Entonces, si cambian las proteínas (antígenos del virus) los anticuerpos pueden no reconocer a esta proteína o reconocerla parcialmente y, entonces, la respuesta inmune no será efectiva”, explica la académica.
Frente a este escenario, Chile además tiene cierta ventaja, pues la circulación de virus respiratorios o la aparición de nuevas cepas se da inicialmente en el Hemisferio Norte, lo que da una ventaja a nuestros científicos y médicos para saber con cierta certeza lo que viene para el siguiente invierno en el Hemisferio Sur.
Para el Dr. Jorge Ramírez, académico del Programa de Salud Global de la Escuela de Salud Pública de la Universidad de Chile, el surgimiento de nuevas cepas sigue siendo altamente probable. “Lo que ocurre cuando avanzan las campañas de vacunación es que la carga viral circulante en la población disminuye y cada vez que el virus se transmite de una persona a otra, existe la posibilidad de que se genere una mutación. Y si esa mutación es compatible o tiene algunas ventajas evolutivas, puede permanecer y transformarse en una nueva variante. Y como esto es probable que se mantenga en el tiempo, la aparición de nuevas variantes sigue siendo posible, cosa que ocurre -por ejemplo- con la influenza”, señala.
All PNI holidays are mandatory by law. However, we do not regularly “persist” those who do not get vaccinated, it is the most productive way to agree or get to know the population to do so. As for the jurisprudence, it may be that in all the instances that have been raised through the courts of justice, the judgments that have been issued in our favor will have to remain vacant.
Why is it mandatory to empty? Dr. Luchsinger is excited about this. “To the immune reaction and, in particular, for the immunocompromised, because in these patients the immune reaction is not good, they respond less to vaccines, because they want reactions. Furthermore, in herbal form the immune reaction will minimize the concentration of antibodies in the blood and increase those quantities by placing the boosters. In addition, it is mandatory to have a new vaccine because the immune reaction induced by vaccines is expected for the variant provided at the beginning of the pandemic, and the one circulating today is very different. The rest of the population will also be advised to collaborate with this bivalent user, because I have already mentioned it,” confides the professor.
For the most vulnerable people, this vaccination is basic, but it can more easily lead to serious complications, hospitalization and probably death, but in healthy people it is not necessary, says the Public Health specialist. It will adhere to the basic principles of vaccination. Now, there is a difference between the issue of individual threat and national threat. Probably, at this point individually, the threat from the other younger ones or those who are outdoors, the risk teams are quite lower and, therefore, the “Recommendation for vaccination without sea to one hundred percent. Also “It is essential that vaccination teams are informed of the costs, as well as the option of having a vaccine available for other people who need to reduce their individual risk,” said Professor Ramírez.
Some other vaccination process will also begin soon. Last week, the first dose of the “Jynneos” vaccine against monkeypox was received, a disease that in Chile already has more than a thousand infections. How is it compatible with all vaccines? Professor Luchsinger says that if a user belongs to a risk group, he prioritizes vaccination against monkeypox and expects at least bivalent glasses against coronavirus.
“This vaccine (against monkeypox) only indicates to other people that they have been in contact with hell and that they are at high risk of contracting a serious infection with this virus, which requires vaccination after exposure, preferably administered in the first four days and up to 1 four days when touching Risk and by symptoms, in specific immunosuppressed, infected patients with HIV and ashamed of any trimester of gestation It is advisable to obtain the monkeypox vaccine at least four weeks before or after. receive a COVID-19 mRNA vaccine to help identify an adverse effect, but otherwise may be prioritized for a monkeypox vaccine,” said Dr. ArrayLuchsinger.
Experts agree that, as is the general rule, vaccine management always aims to leave a space between vaccines of different microorganisms in order to identify possible adverse reactions.
“This is the issue of vaccines that sometimes have some experience. Monoviral vaccines have been used before, but they have never been rolled out with a giant popular escalation. As far as COVID is concerned, while the escalation is so impressive in terms of the number of people vaccinated, it is only a short time that can be monitored. We know that in the progression of the same vaccine as always, before the pandemic, there were more or less years of application before receiving the green light. All this is precipitated to a duration of approximately one year. These are, therefore, vaccines that still exist in a doubtful way in their use in the ideal position to reach a maximum popular escalation and, however, it is vital – within the imagination – to use one separately, for adverse effects. reactions,” said Dr. Ramirez.