Although pregnancy is thought to be a significant threat to coronavirus 2 (SARS-CoV-2) infection of severe acute respiratory syndrome and more severe coronavirus disease (COVID-19), a recent examination through a multinational team of researchers shows that symptoms are comparable between cohorts of pregnant and non-pregnant women, with the exception of gastrointestinal symptoms. This document is available lately on the medRxiv prepress server.
Since the onset of the COVID-19 pandemic, pregnant women were promptly considered a vulnerable organization for increased morbidity and mortality, based on the theoretical dangers of relative immunosuppression pregnancy, as well as previous studies of small coronavirus outbreaks.
But more powerful conclusions required more powerful knowledge. Since its introduction, smartphones and internet programs for population-based syndromic surveillance have citizen science teams that have greatly facilitated the immediate acquisition of extensive epidemiological knowledge as this pandemic evolved.
As a result, researchers from the United Kingdom, the United States and Sweden (led by Dr. Erika Molteni of King’s College London) used this knowledge to verify speculation of whether pregnant women on the network differ in their COVID-19 symptom profile. . and the severity of the disease compared to its non-pregnant counterparts.
This study used a participatory epidemiology technique by leveraging two remote cohorts, which allowed an immediate evaluation of pregnancy by COVID-19. Specifically, the discovery cohort was extracted from 400,750 women from the UK, Sweden and the United States who reported symptoms and occasions through their smartphones, adding 79 pregnant women who tested positive.
On the other hand, the replication cohort extracted from 1344,966 women in the United States consisted of cross-report samples from the active social media user base. In this cohort, 162 pregnant women tested SARS-CoV-2 positive.
In short, the longitudinal nature of the discovery data set opened the door to the prospective comparison of the disease, the time between the onset and peak of symptoms and the specificities of hospitalization between pregnant and non-pregnant women.
The frequency of symptoms and occasions are examined, adding self-formed SARS-CoV-2 tests and the differences between pregnant and non-pregnant women who recovered online and were hospitalized. Multivariate regression strategies were used to explore the severity of the disease and the effects of comorability.
In this study, pregnant women reported more common evidence for the presence of SARS-CoV-2, sometimes did not revel in a more severe disease progression, i. e. the trajectories of the disease on these two teams were similar, while the time between the onset of the disease and the peak of symptoms was only slightly longer in pregnant women than in non-pregnant women (i. e. , 2. 8 versus 2. 2 days).
In contrast, gastrointestinal symptoms were particularly others in pregnant and pregnant women with poor results, with minimal breaks to eat in the discovered cohort and a buildup of nausea/vomiting in the replication cohort.
“Pre-existing lung disease is closely related to the severity of symptoms in hospitalized pregnant women,” the test authors said. “Heart and kidney disease and diabetes were other places of greatest risk,” the test’s authors said.
In addition, express cardiopulmonary symptoms such as chest pain, dyspnoea and persistent cough were most observed in hospitalized pregnant women, leading to the conclusion that cardiopulmonary symptoms are a significant discriminator of hospitalization.
Although pregnancy is widely regarded as a threat to SARS-CoV-2 infection and more severe outcomes, and is certainly linked to increased propensity for detection, the trend of symptoms and severity in these network cohorts are comparable to those observed in non-network people. pregnant women, with the exception of gastrointestinal symptoms.
However, pregnant women with significant cardiopulmonary symptoms or pre-existing lung disease may require special attention during the ongoing COVID-19 pandemic. In short, lung disease had the greatest effect on the severity of the disease during pregnancy.
“Doctors should be more attentive to pregnant women who have pre-existing fitness problems, significant respiratory symptoms or a higher severity index, such as the general population,” according to the authors of this medRxiv study.
In all cases, other studies that target high-risk pregnancies and results at 3 trimesters are warranted in order to improve the definition of outcomes in this population. It is also mandatory to interpret severity indices and hospitalization rates in a gentle form of policy. changes, which would possibly depend on the context or the country.
medRxiv publishes initial clinical reports that are not peer-reviewed and are therefore not considered conclusive, clinical practices/health-related behaviors, nor are they treated as established information.
Written by
Dr. Tomislav Me-trovio is a physician (MD) with a degree in biomedical and fitness sciences, specialist in the area of clinical microbiology and assistant professor at the youngest University of Croatia – University North, in addition to his interest in clinical activities. , and lectures, his immense pastime in medical writing and clinical communication goes back to his student days. He likes to contribute to the community. In his free time, Tomislav is a filmmaker and a wonderful traveler.
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