Earlier this month, shortly before Ohio Gov. Mike DeWine met with President Donald Trump at a Cleveland airport, the governor tested positive for a quick antigen check for the new coronavirus, SARS-CoV-2, which causes COVID-19 disease.
Two follow-up tests, a more accurate polymerized chain reaction or a PCR test, showed that the governor did not have the virus.
This type of false positive with antigenic control is a remote incident.
Dozens of others who underwent immediate sarS-CoV-2 control evolved through biotechnology company Quidel at a clinic in Manchester, Vermont, in July, were told they had the virus.
Subsequent PCR tests conducted through the State Ministry of Health revealed that four of those 65 tested positive.
With others in the United States returning to paintings and school, and stealing and eating in restaurants, businesses, businesses, and universities are using immediate testing to identify others with the virus.
But no verification is absolutely accurate, which means that some instances (false negatives) will be overlooked and that other people will be informed that they have the virus even if they do not (false positives).
This can create confusion, especially when others don’t know what kind of verification they’ve done.
But some experts say widespread testing, even if less accurate, may still involve the COVID-19 pandemic in the United States.
There are 3 coronavirus tests:
The Centers for Disease Control and Prevention (CDC) considers PCR testing to be the “gold standard” for SARS-CoV-2 testing. These tests are conducted through laboratories in hospitals, universities and public fitness agencies.
Some labs can process samples in 1 day, but it takes much longer; other people wait a week or more to see if they’ve tested positive.
Antigen tests can be done more temporarily, with effects in as little as 15 minutes, with saliva or a nasal buffer. Like PCR tests, antigenic tests show if someone has an active infection.
Although antigen tests are faster and the number of tests performed can be easily increased, they have a maximum rate of false negatives, with up to a portion of the negative results incorrect.
The Vermont Department of Health considers positive antigenic control as a positive case only if it has been demonstrated by PCR control. Other states have procedures.
But PCR testing is not accurate. Some studies have shown that up to 29% of these tests can give false negatives.
The accuracy of those s, whether PCR and antigen, varies significantly depending on their manufacturer.
Other points could possibly also be the results: how a nasal swab or saliva pattern was taken, how the pattern was transported, how a user plays the check (and whether he was well trained) and the device used.
The goal of testing is to identify others who have SARS-CoV-2 infection so they can pass it on to others.
But if other people don’t get its effects for 2 weeks or more, it doesn’t matter how accurate the test is. They’ve already missed an opportunity to isolate themselves.
Laboratories can be delayed to some extent by adding more appliances and technicians, or by automating procedures.
Some experts have also proposed grouped tests, in which samples are combined before testing. If a batch is positive, individual samples, or smaller sample computers, are analyzed, reducing the number of tests to run.
However, Dr. Alexis Nahama, senior vice president of diagnostics at biotechnology company Sorrento Therapeutics Inc. in San Diego, he says it’s hard to trump delays by simply expanding the number of PCR machines.
“In order to run the checks on a giant scale, you must be able to decentralize the place where the verification is performed,” he said. “That’s why you want medical offices and dental offices to perform the checks. minilabs that can perform many checks at airports. “
Rapid and undeniable control in schools, restaurants, airports and stadiums would allow those sites to identify the inflamed before entering, reducing the threat of transmission in public places.
Sorrento is running in the marketing of an immediate check that evolved through Dr. Zev Williams and his team at Columbia University Fertility Center in New York.
They may encounter the presence of RNA from the new coronavirus in a saliva pattern in as little as 30 minutes. If positive, the color of the liquid in the tube changes to yellow.
Preliminary research shows that control is very accurate, as is a PCR control, but unlike PCR controls, which require specialized equipment, Sorrento saliva control requires a heating block.
“This verification would be ideal for a medical practice, a hotel before other people check in or at the airport before others fly,” said Dr Mark Brunswick, Sorrento’s senior vice president of regulatory affairs.
He adds that the company plans to submit a request for approval of his saliva to the Food and Drug Administration (FDA) until the end of next week.
Others agree on the need for decentralized testing.
Dr. Michael Mina, Professor of Epidemiology at Harvard T. H. Chan School of Public Health in Boston contends that the US and its allies in the Middle East have been able to do so. But it’s not the first time They check almost every one and every one in the country almost every day, which means conducting tens of millions of checks a day.
To do this, the tests must be simple, reasonable and available everywhere.
But Bobby Brooke Herrera, PhD, co-founder and CEO of biotech corporate e25 Bio, told The Atlantic that because the FDA compares newly conducted coronavirus tests to the PCR test, corporations that expand tests on accuracy at the expense of speed and convenience.
E25 has developed a paper verification strip that can detect SARS-CoV-2 infection in 15 minutes with a saliva sample and has still been approved by the FDA.
Opening the door to less accurate testing for the general public means rejecting the PCR altogether. Hospitals and other places that want very rapid effects will continue to use this type of test.
But for large-scale testing, less accurate testing can continue to work.
In a STAT News article, Dr. Jeffrey L. Schnipper and Paul E. Sax, both professors of medicine at Harvard Medical School, explain how less accurate tests can help fight the pandemic, if tests are done enough.
“Even if the verification isn’t perfect, it’s much greater than what we’re doing now, which hardly checks without symptoms,” they wrote, “partly because of accuracy issues of verification. “
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