Using a new strategy that allows high-resolution images of broken lung tissue, scientists have discovered adjustments caused by severe COVID-19 in the design of blood vessels and organ air sacs, findings that can help the progression of new opposite remedy strategies to the disease.
In the study, published in the journal eLife, scientists developed a new X-ray strategy that allows high-resolution three-dimensional images of inflamed lung tissue to be obtained with the new SARS-CoV-2 coronavirus.
Using this new method, the researchers, who added those from the University of Gottingen in Germany, observed significant adjustments in blood vessels, inflammation and a deposit of proteins and dead cells in the walls of small air sacs of the lungs called alveoli. They said these adjustments make fuel exchange through the organ complicated or impossible.
According to scientists, the new imaging technique will allow to visualize these adjustments for the first time in higher volumes of tissue, without cutting and dyeing or damaging the tissue.
They said it is very suitable for insinuating small blood vessels and their branches in 3 dimensions, locating the immune formula that cells provide at inflammation sites and measuring the thickness of alveolar walls.
Due to three-dimensional reconstruction of lung tissue, the researchers said knowledge can also be used to simulate fuel exchanges in the organ. Because X-rays penetrate deep into tissues, they said scientists can use the approach to perceive the dating between the microscopic arrangement of tissues and the broader function of an organ.
“Based on this first proof-of-concept study, we propose multi-scale phase contrast X-ray tomography as a tool to get to the bottom of COVID-19 pathophysiology,” the researchers wrote in the study. Scientists believe this strategy will help the progress of remedies and medications to save it or mitigate severe lung damage caused by COVID-19 or to promote healing.
“Only when we can obviously see and perceive what is happening will we be able to expand specific interventions and medications,” said Danny Jonigk, co-author of the study at Hanover Medical University in Germany.
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