In the study, published in the journal eLife, scientists developed a new X-ray strategy that enables high-resolution three-dimensional images of inflamed lung tissue with the new SARS-CoV-2 coronavirus.
Using the new method, the researchers, who added those at the University of Gottingen in Germany, observed significant adjustments to blood vessels, inflammation and a deposit of dead proteins and cells in the walls of small air sacs of the lungs called alveoli.
They said these adjustments make exchanging fuel through the organ complicated or impossible.
Scientists say the new imaging technique makes it imaginable to visualize those settings for the first time in larger, uncut, dyeing, or damaging tissue tissue volumes.
They said it is very suitable for insinuating small blood vessels and their branches in 3 dimensions, locating the immune formula that cells provide at inflammation sites, and measuring the thickness of alveoter walls.
Due to the three-dimensional reconstruction of lung tissue, the researchers said knowledge can also be used to simulate fuel exchanges in the organ.
Because X-rays penetrate deep into tissues, they said scientists can use the approach to perceive the dating between the microscopic arrangement of tissues and the broader function of an organ.
“Based on this first proof-of-concept study, we propose multi-scale phase contrast X-ray tomography as a tool to get to the bottom of the pathophysiology of COVID-19,” the researchers wrote in the study.
For scientists, this strategy will help advance remedies and medications to save or mitigate severe lung damage caused by COVID-19, or to promote healing.
“Only when we can obviously see and perceive what is happening can we expand specific interventions and medicines,” said Danny Jonigk, co-author of the study at Hanover Medical University in Germany.
This story was published from a firm thread without converting the text. Only the name has been changed.
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