The Chinese coronavirus vaccine being developed through the Institute of Medical Biology has been declared through researchers after the final touch of phase 1 clinical trials. Researchers claimed that the inactivated SARS-COV-2 vaccine produced and produced an immune reaction in the control subjects and that there were no adverse effects instead of mild pain, injection site redness or mild fatigue.
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The study was published in the medical journal medRxiv on October 6 so that it can be evaluated and reviewed through the clinical community. In phase 1 of clinical trials, the randomized, double-blind, placebo-controlled approach was used to check the vaccine in 192 healthy elderly adults aged 18 to 59. Two injections of another 3 doses (50 EU, 100 EU and 150 EU) of an inactivated SARS-COV-2 vaccine or a placebo with a period of 2 or four weeks between injections were administered intramuscularly. The protection and immunogenicity of the vaccine were evaluated within 28 days.
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According to the study, 191 subjects completed the 28-day trial and 44 adverse occasions were reported between the period; however, the effects were not as severe and no variations were observed in serum samples from immune subjects.
A total of 294 adults over the age of 18 to 59 were evaluated for inclusion in this Phase 1 trial; of these, 102 other persons were excluded, 84 of whom were not eligible and 18 withdrew their informed consent. The remaining 192 participants were randomly assigned to a ratio of 1:1 to obtain two inoculations with an interim period of 14 days or 28 days, and the program subjects were assigned to a ratio of 1: 1: 1: 1 to obtain one, three doses of the vaccine or placebo.
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The inactivated SARS-CoV-2 vaccine evolved through the Institute of Medical Biology (IMB), Chinese Academy of Medical Sciences (CAM S). In summary, the viral strain, called KM S-1, was inoculated into Vero cells for its production in a The collected viruses were inactivated with formaldehyde for 48 hours to lyse the viral membrane, were purified by chromatography and concentrated, according to the study. .