By the Washington Post Isabelle Khurshudyan, Carolyn Y. Johnson WORLD, HEALTH, EUROPE, HEALTH NEWS
277 views
Officials have pledged to deliver the vaccine to millions of others this summer and fall, adding tens of thousands of teachers and number one physical care staff in the coming weeks before clinical trials have ended, with the formula developed through the Gamaleya Institute in Moscow. .
But Russia’s tough accusations of a possible vaccine have alarmed global fitness experts that the country is jumping dangerously in the face of large-scale critical tests that are essential to determine whether the imaginable coverage opposed to covid-19 is safe and effective. Few main points of Gamaleya’s studies have been made public or peer-reviewed.
Konstantin Chumakov, a member of the Global Virus Network, a foreign coalition working on viral threats, said it is “scientifically effective” without large-scale testing, known as Phase 3.
“Using it in the general population before the effects of Phase 3 trials are studied is a bet,” he said. “Russian roulette, so to speak.”
The vaccine is called Sputnik V, a reference to the first orbital satellite, which was introduced through the Soviet Union in 1957 and triggered the area’s global career. The call also referred to how Putin’s government regarded the vaccine race as a national pride and global competition, with laboratories in the United States, Europe, China and elsewhere also looking for a possible vaccine.
“Of course, what matters most to us is ensuring the unconditional protection of the use of this vaccine and its effectiveness in the future. I hope this will be achieved,” Putin said in an assembly with government officials on Tuesday. he added that one of his two daughters had won the possible vaccine against Gamaleya. He didn’t identify which girl.
Russian laboratories rush to locate the vaccine during the fall, but considerations on accelerated methods
A country’s competitive strategy seeking victory amid one of the world’s worst epidemics has been criticized by outdoor scientists who worry that the shooting may be destructive or give others a false sense of security about their immunity. China already has a legal vaccine to be used in its armed forces, before having definitive knowledge that it is effective.
“He listens to us [again] at the time of Sputnik,” he added. “It reminds us of the glorious days of Russian science, sets in motion the Russian propaganda device. I think it can be counterproductive.”
– – –
Foreign combat for a vaccine has exacerbated considerations of vaccine nationalism, in which the desire for countries to be victorious about the pandemic may simply circumvent long-standing safeguards for others of unprotected medical products by ensuring that their benefits outweigh the risks.
For Russia, leading the vaccine race is a path to greater geopolitical influence. But the country also seeks to look dependent on Western powers, with whom relations are traditionally poor, analysts said.
Last month, security officials from the United States, Britain and Canada accused hackers connected to a Russian intelligence service from seeking to borrow data from studies being running to produce coronavirus vaccines in those countries.
For countries, it is difficult to recognize that “how is it possible that Russia, which has at all times presented itself as this backward and authoritarian country, can do so?” Dmitriev said last week.
Dmitriev said Russia has won initial applications for more than one billion vaccine doses from 20 countries and is able to manufacture more than 500 million doses of vaccines in five countries.
Russia’s resolution could create political tension in other countries to bet on an unproven vaccine.
This is a major fear because adverse reactions of the vaccine are much less likely to be reported transparently if administered outdoors from a rigorous trial. There is also fear, Morrison said, that others will be forced to take an unproven and potentially harmful vaccine to keep their jobs.
“We see, in every country, the tension between the political desire to show the public that it is doing something useful and the clinical reluctance to act only when a vaccine is effective,” said Mark Poznansky, Director of Vaccines and Immunotherapy. Center at Massachusetts General Hospital.
– – –
At a Congressional hearing this month, Anthony Fauci, director of the National Institute of Allergy and Infectious Diseases, said it would be problematic if countries made a vaccine before extensive testing.
“I hope that the Chinese and Russians will check the vaccine before administering the vaccine to someone, because the claims that a vaccine is in a position to be distributed before verification are, I think, problematic in the most productive,” Fauci said.
The threat is basically monetary: if vaccines are unsuccessful in large-scale clinical trials, they will not be used.
The main Russian candidate vaccine has so far been tested in small initial clinical trials designed to locate the correct dose and evaluate any protection issues. It was given to the scientists who developed it, as a component of a self-experiment in fashion science, as well as 50 members of the Russian army and a handful of other volunteers.
Dmitriev said Russia would move forward with Phase 3, a larger trial involving thousands of participants considered a key precursor to regulatory approval. Parallel trials are planned in Saudi Arabia, the United Arab Emirates and, in all likelihood, in Brazil and the Philippines, he said.
The state of Paraná in southern Brazil has announced that it will begin generating an imaginable Russian vaccine in November.
Russia also intends to start the possible vaccine on medical staff and frontline teachers who consent to it, who will be asked to document how they feel.
But while Russian officials continually trusted that the vaccine was safe, Dmitriev could not tell if it had been tested on a user who was already inflamed by the coronavirus. Some vaccines, such as the one that developed as opposed to dengue and used in the Philippines, can make the disease worse.
“We’ll have tens of thousands of other people vaccinated this way in August,” Dmitriev said.
The World Health Organization lists the Gamaleya vaccine as in phase 1.
WHO spokesman Tarik Jasarevic said at a briefing in Geneva that “we are in close contact with the Russian government of fitness and discussions are ongoing on possible detection of the vaccine by WHO.”
“But again,” he continued, “the prequalification of any vaccine includes a rigorous review and all required protection and efficacy data.”
– – –
Most of what external scientists know about the experimental vaccine comes from second-hand sources, not published medical studies. Dmitriev stated that, while this would possibly be elsewhere, Russia has historically been reserved in its clinical efforts.
“You have to think a little bit about the Russian system; after Sputnik flew for five days, it was not until the fifth day that Russia identified that there was a satellite in flight,” he said.
The Russian vaccine uses two doses to administer other innocent bloodless viruses, or adenovirus, which are designed to carry the bristly protein gene that surrounds the outside of the coronavirus to the cells.
The technique encouraged through Gamaleya Ebola vaccines evolved in 2015 and 2018. But while Putin boasted this year that Russia’s Ebola vaccine “has proven to be the highest effectiveness in the world,” WHO still classifies it as a “candidate vaccine” on its website.
Adenoviruses are also used by scientists from pharmaceutical company Johnson and Johnson, CanSino Biologics of China and the University of Oxford in their candidate vaccines.
But these other efforts published knowledge about the functionality of the vaccine in animals ranging from mice to monkeys, and also presented knowledge of early human trials showing the severity of any reaction, ranging from pain in injection to fever.
The CanSino vaccine uses one of the same innocent viruses that Russians use in their vaccine, and its effects have been disappointing for some scientists.
Dmitriev said his non-public confidence in the Russian vaccine was so superior that he, his wife and their parents, either over 70, were subject to control. He said only his wife reported mild fever on the first night of the injection.
“These are crazy Russians who use crazy things that have been shown,” Dmitriev said. “Adenovirus has been in humans for thousands of years, and we bet on this platform shown because we perceive that its progression takes very little time, given the challenges.”
ONLINE ADVERTISING
Contact: Sirintip Yutika Mobile (66 80818 8187)
Email: [email protected]