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New studies provide more data on effective or useless remedies for COVID-19, with strategies that yield reliable results.
British researchers published friday their studies on the only survival-enhancing drug: a reasonable steroid called dexamethasone. Two other studies have shown that hydroxychloroquine, an antimalarial medicine, does not affect others with mild symptoms.
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For months before studies like these, learning what is helping or the night has been undermined through the “science of despair,” as doctors and patients tried treatments or a series of studies that were strong enough to provide transparent responses.
“For the picture to progress and patient outcomes to improve, fewer small or inconclusive studies” and more like the British, the Drs. Anthony Fauci and H. Clifford Lane of the National Institutes of Health wrote in the New England Journal OF Medicine.
Now is the time to do more studies comparing remedies and combinations of evidence, said Dr. Peter Bach, a fitness policy at Memorial Sloan Kettering Cancer Center in New York.
Here are the highlights of the advances in treatment:
The British study, led by oxford University, tested a type of steroid widely used to decrease inflammation, which can be severe and fatal in the latter stages of COVID-19.
Approximately 2,104 patients who won the drug were to 4,321 patients who received regimen care.
It reduced the number of deaths by 36% in patients with health problems enough to want breathing apparatus: 29% of the drug died compared to 41% of the same previous care. Reduced the death threat by 18% for patients who only wanted an oxygen supplement: 23% of the drug died compared to 26% of others.
However, this gave the impression of being destructive at an early level or in milder cases of disease: 18 consistent with one hundred of those receiving remedy died compared to 14 consistent with one percent of those who received normal care.
The clarity of who benefits and who will not “lead to many saved lives,” Fauci and Lane wrote.
The same Oxford test also rigorously tested hydroxychloroquine and researchers in the past stated that it did not help patients hospitalized with COVID-19.
After 28 days, approximately 25.7% of hydroxychloroquine had died and 23.5% received the same attention above, a difference so small that it may have happened by chance.
Now, the main points published on a research site for scientists show that the drug would possibly have hurt. Patients who received hydroxychloroquine were less likely to leave the hospital alive within 28 days: 60% in treatment compared to 63% who received normal care. Those who did not want breathing apparatus at the beginning of the remedy were also more likely to take one or die.
Two other experiments showed that the early remedy with the drug did not help outpatients with mild COVID-19.
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An examination of 293 other people in Spain published in the journal Clinical Infectious Diseases did not find a significant difference in reducing the number of patients inflamed with the virus, the threat of worsening and the need for hospitalization, or recovery time.
A similar examination by doctors at the University of Minnesota at Annals of Internal Medicine among 423 patients with mild COVID-19 found that hydroxychloroquine did not particularly decrease the severity of symptoms and produced more side effects.
“It’s time to move” to the treatment of patients with this drug, Dr. Neil Schluger of New York Medical College wrote in an observation in the journal.
The only other remedy that has been shown to help patients with COVID-19 is remdesivir, an antiviral that shortens hospitalization by an average of about 4 days.
“The role of repobreza in serious COVID is now what we want to understand,” Bach of Memorial Sloan Kettering wrote in an email, saying that the drug should now be tested in combination with dexamethasone.
Related: Therapeutic studies are accelerating as COVID-19 instances accumulate in the United States.
Details of the government’s review of remdesivir have still been published, but researchers are eager to see how many patients have gained other drugs, such as steroids and hydroxychloroquine.
Meanwhile, Gilead Sciences, the company that manufactures remdesivir, which is now administered intravenously, has begun testing an inhaled edition that would allow it to be tried in patients with COVID-19 less patients to verify that they prevent them from having health problems. want it Hospitalization. Gilead also began testing remdesivir in a small children’s organization.
Supplies are very limited and the U.S. government. He’s assigning doses to hospitals until September.
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