We delve into the popular world of vaccine adjuvants, with a specific focus on QS-21, a purified plant extract derived from the local soap bark (Quillaja saponaria) from Chile, Peru, and Bolivia. Known for its potential to increase the efficacy of vaccines. Water-soluble triterpene glycosides QS-21, a type of compound called saponins, which are thought to boost humoral and cell-mediated immunity. During the discussion, the importance of QS-21 as a vaccine adjuvant and its implications for vaccine progression were discussed.
LL: Could you give us an overview of the challenging situations BSI faced when purchasing the QS-21 and how it overcame them?
GS: Demand for QS-21 has been high, but classic extraction strategies have run into obstacles due to deforestation legislation and problems with the chain of origin. At BSI, we have developed a unique technique to grow those trees in our laboratories and extract QS-21 from them while they are in vitro. This technique allows us to meet demands sustainably and consistently.
LL: Can you tell us more about the first steps in the progression of this approach and the obstacles you encountered?
LL: It feels like a journey; How did you feel when you discovered the magnitude of this innovation?
GS: At first, it was hard to understand the effect our painting could have on agriculture and physical care alone. We had to deal with skepticism from our board of directors and investors, but we stayed true to our vision. Gaining traction among the pharmaceutical giants validated our efforts and increased our confidence.
LL: Nature has a lot to teach us. Could you explain the importance of QS-21 in vaccine production and why it has been difficult to obtain?
GS: QS-21 has played a critical role in the progression of adjuvant systems and vaccine efficacy. Although it has been around for decades, advances in formulas achieved through corporations such as GSK have boosted its use in highly successful vaccines such as Shingrix. However, classical extraction strategies employing destructive biological solvents and limited availability of the compound have hindered its widespread use.
LL: It’s a real bottleneck in vaccine development. What is BSI’s technique for finding and extracting resources to address these challenges?
GS: Our goal has been to optimize the initial tree development and extraction procedure for QS-21, making it more cost-effective and scalable. By perfecting our plant tissue culture and genetic manipulation techniques, we aim to produce trees that naturally produce higher quantities. from QS-21. Furthermore, inventions in subsequent production and purification systems will increase the accessibility of QS 21.
LL: What key milestones has BSI achieved and what partnerships are on the horizon?
GS: BSI has gained popularity in the industry for its cutting-edge approach, winning several awards for our processes and products. Our partnerships with pharmaceutical giants have validated the quality and efficacy of our QS-21. In the future, we aim to expand collaborations with vaccine developers. and generation corporations to advance vaccine adjuvant systems.
LL: Could you tell us about BSI’s plans and aspirations?
GS: Our ultimate goal is to become a full-fledged pharmaceutical company, using our unique compounds to expand new vaccines and treatments. Taking advantage of the good fortune of the QS-21, we plan to exploit other derivatives of the same tree to control a wider range. diversity of diseases. By combining the most advanced generation with nature-inspired solutions, we aim to make a lasting impact on global healthcare.
LL: Any definitive thoughts on BSI’s adventure and its importance in the pharmaceutical industry?
GS: BSI’s adventure exemplifies the strength of innovation and sustainability to tackle critical healthcare challenges. By harnessing nature’s resources and harnessing biotechnology, we are paving the way for a more resilient and equitable vaccine landscape. Our story underscores the importance of collaboration and perseverance in driving meaningful change.
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