Abu Dhabi: On Monday, Abu Dhabi announced that it would soon host Phase III trials for some other COVID-19 vaccine, this is the time for a Phase III trial in the United Arab Emirates for a COVID-19 vaccine, while the first evolved in China, the moment evolved in Russia.
Residents will soon be invited for testing, here’s what we know about this vaccine and the tests in the UAE so far.
This specific COVID-19 vaccine evolved in Russia and was created through the National Research Institute of Epidemiology and Microbiology of Gamaleya of the Russian Ministry of Health. Gamaleya, a Moscow-based medical studies institute, is named after Russian scientist Nikolay Gamaleya, a pioneer in microbiology and vaccine studies.
According to the official website, the Russian vaccine called Sputnik V, in reference to the Soviet Union’s success area program that introduced the world’s first satellite, Sputnik 1, Earth’s first synthetic satellite, and was successfully introduced into Earth’s orbit in 1957.
The vaccine uses adenoviral vectors, human adenovirus whose genetic layer has been eliminated, which induces the immune formula of the receptor to produce an immune response, unlike THE COVID-19 genes transported through the inactivated adenovirus. The first dose of Sputnik V uses the vector adenoviral rAd26, while the dose currently uses the vector adenoviral rAd5.
According to the developers, a gene with the code of a coronavirus S protein (tip) is inserted into an adenoviral vector during the vaccine creation process. The inserted component is safe for the human body, but it still helps the immune formula react and produce the antibodies that protect us from infection.
According to the official website, 3 adenoviral vector vaccines have already been approved for Ebola and have been used to vaccinate 60,000 other people in Russia, China and other countries. China is also reported to have two cancer drugs on the adenoviral vectors.
Other vaccine developers are also human adenovir vectors for their COVID-19 vaccine candidates, adding Oxford University and Johnson
The official online page for the vaccine also states that “the use of human adenoviruses as vectors is because these viruses, which cause colds, are not new and have been around for thousands of years. “
First, preclinical animal trials were carried out, adding two types of primates.
On 1 August, Russia completed the first two stages and the country approved Sputnik V as a COVID-19 vaccine on 11 August.
Alexander Gintsburg, director of Gamaleya, told foreign media that the school of studies had already won the vaccine, in addition to Russian soldiers, other volunteers and, as is well known, the daughter of the Russian president.
The effects of those early human tests of Sputnik V were published in a famous medical journal, The Lancet, in September. In all, 76 other people participated in the trials, and the vaccine produced a strong overall immune reaction. Also, only a slight appearance effects have been reported.
The Lancet also reported that large-scale clinical trials of the vaccine, involving more than 40,000 people, were scheduled to begin in Russia in the last week of August.
“Several countries, such as the United Arab Emirates, Saudi Arabia, the Philippines and in all likelihood India or Brazil, will be enrolled in Sputnik V clinical trials,” the vaccine developer announced on its official website.
Russia’s Direct Investment Fund, RDIF, Russia’s sovereign investment fund, has partnered with Aurugulf Health Investment, a newly established investment firm in the UAE, to conduct vaccine testing.
The trials will be conducted through the Abu Dhabi Department of Health (DoH), the emirate’s fitness regulator, overseeing the Ministry of Health and Prevention of the United Arab Emirates (MoHAP). Provider, Abu Dhabi Health Services Company (Seha).
Details of these main points are expected to be announced through DoH and MoHAP in the coming days. However, Phase III trials involve a few thousand people.
The effects of provisional tests of the Russian vaccine are also expected to be by the end of November.
Most viral vector vaccines require more than one dose to generate the desired effect. In the case of the Sputnik V vaccine, Gamaleya says vaccines are given two doses 21 days apart.
The president of the Department of Health, Sheikh Abdulla bin Mohamed Al Hamed, said that “the organization of a THIRD COVID-19 vaccine trial in Abu Dhabi reaffirms our lasting commitment to collaborate in global responses to the demanding situations presented by this pandemic. “
“With our world-class healthcare infrastructure, the strength of our study ecosystem, and the volunteer spirit of the community, Abu Dhabi is an exciting prospect for those advancing clinical discovery.
Similarly, in the case of the first Phase III trials for a COVID-19 vaccine in the UAE, the developers cited the UAE’s diverse demographic base as one of the main reasons why it selected for testing.
The first III trials in the UAE concerned an inactivated vaccine developed through Chinese pharmaceutical giant Sinopharm China National Biotec Group.
These trials were also supervised by DoH and MoHAP, with medical protocols controlled through Seha. They were led through the health care wing of Abu Dhabi-based Corporate Group 42, which has a supercomputer that can be used to analyze the results.
Trials began on July 16 and first affected 15,000 volunteers. However, in six weeks, more than 31,000 volunteers had registered and registration in the UAE was closed on 31 August.
Like Sputnik V, the Chinese COVID-19 vaccine tested in the United Arab Emirates required volunteers to obtain two doses 21 days apart.
On September 15, the vaccine obtained emergency regulatory approval for use with frontline staff. Several senior officials and frontline staff have already won either dose of the vaccine. Although the effects of official trials are pending, officials announced last month that the Chinese vaccine had been tested on 1,000 chronic volunteers and no adverse effects or headaches had been observed.
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