Coronaviruses are a giant circle of virus relatives that can infect both animals and humans. It is a respiratory virus named after the crown-shaped peaks on its surface. These viruses are to blame for various epidemics around the world.
There are seven known types of human coronavirus, in which 4 types, KHU1, OC43, NL63, and 229E, cause mild to moderate respiratory infections, such as colds. However, two types cause severe respiratory infections: severe acute respiratory syndrome (SARS-CoV) coronavirus and Middle East Respiratory Syndrome (MERS-CoV) coronavirus. The seventh type of coronavirus is the new SARS-CoV-2 coronavirus that has spread from China to the rest of the world, infecting about 20 million people.
Now, a new test shows that other people have immune reactions opposed to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the virus that causes COVID-19, thanks to the reaction of the picture the last time a cold became stuck. This means that even if a user has not been exposed to the new coronavirus, the frame is reminiscent of it and can cause an immune reaction to fight the infection.
Researchers at the La Jolla Institute of Immunology (LJI) have found that past infections with the blood-free viruses KHU1, OC43, NL63 and 229E can cause the immune formula to be tripped and recognized by SARS-CoV-2.
Published in the journal Science, the study highlights the immune system’s ability to fight infections and diseases. The team revealed that immune cells, called T cells, which may stumble upon non-unusual bloodless coronavirus, may recognize sites of expression of the virus, such as the “pic” protein. This type of protein is used through the virus to bind and invade healthy human cells.
To succeed in their findings, the team used human blood samples prior to the discovery of SARS-CoV-2 in December 2019. From there, they mapped 142 T-mobile epitopes in the SARS-CoV-2 genome to facilitate accurate SARS interrogation. – Mobile repertoire Cd4 T – express to CoV-2.
“We demonstrated a diversity of pre-existing T cells reminiscent of CD4 that have cross-reactivity with a comparable affinity for SARS-CoV-2 and non-unusual bloodless coronaviruses HCoV-OC43, HCoV-229E, HCoV-NL63 or HCoV-HKU1. For example, reminiscent of T cells with coronaviruses that cause absence of blood may be the basis of at least some of the broad heterogeneity observed in COVID-19 disease,” the researchers concluded in the study.
The team also found that 40 to 60% of others who had never been exposed to SARS-CoV-2 had T cells that responded to the virus. The immune formula of these other people has identified fragments of the virus that they had never noticed before, possibly explaining why some only spread mild symptoms and why some are asymptomatic.
Despite the promising results, the researchers said more studies and knowledge collection are still needed to achieve a more conclusive outcome.
“We have now shown that, in some other people, reminiscent of pre-existing T cells opposed to non-unusual bloodless coronaviruses may recognize SARS-CoV-2, even precise molecular structures. This can help others have milder symptoms of the disease, while others become seriously ill,” said Daniela Weiskopf, an assistant professor of studies at the LJI.
Meanwhile, Professor Alessandro Sette, co-author of the study, said immune reactivity can result in varying degrees of protection. In others with a physically powerful T mobile reaction, they have the ability to mount a faster and more physically powerful reaction to the virus that causes COVID-19.
Understanding the SARS-CoV-2 mechanism can help scientists expand remedies and vaccines that oppose the coronavirus pandemic. These studies can accelerate the discovery of healing products involving the spread of the fatal virus that has killed more than 731,000 people.
The coronavirus pandemic has reached 188 countries and territories, infecting 19.86 million people. The United States remains the country with the number of instances shown, reporting more than five million instances and more than 162,000 deaths. Brazil and India report the highest transmission rates, with more than 3 million and 2.2 million instances, respectively.
Of these, the official count showed more than 11.96 million cures after SARS-CoV-2 infection. WHO has stated that the new epicenter of the pandemic is in the Americas. Brazil, Peru, Colombia and Chile in South America report the highest number of cases shown.
Written by
Angela is a career and heart nurse. He graduated by far (Cum Laude) from his Bachelor of Nursing from the University of Baguio, Philippines. Lately she is completing her master’s degree where she specialized in maternal and child nursing and has worked as a clinical instructor and educator at the School of Nursing at the University of Baguio.
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