Biotechnology company Novavax will soon begin the human moment phase for its COVID-19 vaccine.
The so-called Phase 2b clinical trial will come with an organization of 2665 healthy adults in South Africa, as well as an organization of 240 adults with HIV who are considered medically robust but whose immune responses may differ from others without HIV.according to a statement published through Novavax on August 17.HIV advocacy teams have lobbied for other HIV-positive people to participate in co-trials of COVID-19 vaccines, and corporations such as Moderna and Pfizer first said they would exclude volunteers with the infection, Science Magazine reported.
In a previous phase 1 protection trial of the Novavax vaccine, healthy volunteers who won two doses of the vaccine showed only mild side effects, such as headache, fatigue and tenderness, or injection site pain, according to a report published on August 6 to The medRxiv Prepress Server.Based on these initial data, which have not been peer-reviewed, all Phase 1 participants also generated neutralizing antibodies, which can prevent the virus from entering cells after receiving a momentary dose of the vaccine.to compare this immune reaction in the Phase 2b trial in South Africa, as well as in a phase 2 trial to be conducted in the United States and Australia “in the near future,” according to the statement.
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“Because South Africa is experiencing a winter outbreak of COVID-19 disease, this Phase 2b clinical trial has the prospect of providing an early indication of efficacy as well as greater knowledge about the protection and immunogenicity of [the vaccine],” said Dr. Gregory Glenn, president of studies and progression for Novavax, said in the statement that South Africa is the fifth most affected country in the world in terms of COVID-19 cases and related deaths , with 583,653 cases reported and 11,677 deaths as of August 17, Reuters reported.
Novavax’s trial in South Africa will be funded through the Bill Foundation
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The vaccine, called NVX-CoV2373, proteins derived from the complex coronavirus protein, a design that protrudes on the surface of the virus and connects to cells to cause infection, according to the release.In general, Novavax designs vaccines by binding those proteins to microscopic wastes that can be administered under the framework to cause an immune response, according to the New York Times Coronavirus Vaccine Tracker.
Novavax has also added an adjuvant to the vaccine, an additional element that helps recover cells immune to action.Specifically, the adjuvant in NVX-CoV2373 comprises a saponin, or a plant-derived chemical compound, according to the communiqué.summon immune cells to the injection site, where they identify foreign proteins, such as complex protein, and “present” those proteins to T cells; those T cells then what proteins look like if a vaccinated user were exposed to the virus, according to a 2016 report in the journal Nature Communications.
Originally on Live Science.
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