By Brenda Goodman, CNN
Updated Covid-19 boosters that include commands to assemble the framework instead of recently circulating Omicron subvariants offer some coverage against infections, according to the first study I read about the real-world functionality of the boosters. However, coverage is not as superior to that provided through the original vaccine against previous variants of the coronavirus, according to the researchers.
Dr. Anthony Fauci, director of the National Institute of Allergy and Infectious Diseases, called the new knowledge “good. “
“Please, for your own protection, for the protection of your circle of relatives, update your Covid-19 vaccine as soon as you are eligible to protect yourself, your circle of family and your community,” Fauci said at a White House Briefing Tuesday.
Absorption of bivalent boosters, which oppose BA. 4/5 subvariants as well as the original virus strain, has been remarkably slow. Only 11% of eligible Americans have received them since they became available in early September.
The new study found that the updated reinforcements look quite similar to the original reinforcements. They protect against symptomatic infections in the range of 40% to 60%, meaning that even when vaccine protection is strongest, about a month after receiving the vaccine, other people may still be vulnerable to advances in infections.
That’s about the same diversity as typical flu vaccine effectiveness. Over the past 10 years, CDC knowledge shows that the effectiveness of seasonal flu vaccines has ranged from a low of 19% to a high of approximately 52% compared to the need to see a doctor. due to the flu. Effectiveness varies depending on how the strains in the vaccine are the strains that end up making other people sick.
The authors of the new study say other people know that COVID-19 vaccines no longer offer coverage of more than 90% compared to symptomatic infections, as they did when they were launched in 2020.
“Unfortunately, we saw 90% to 100% coverage in the pre-Delta period. So with Delta, we saw it fall to the 70% range, and then for Omicron, we saw it fall even further, to 50%. % range. So, I think what we’re seeing here is that the bivalent vaccine actually brings you back to that kind of efficacy that we would have noticed without delay after the boosters beyond, which is great. That’s where we need it to happen,” said Dr. Ruth Link-Gelles, an epidemiologist at the U. S. Centers for Disease Control and Prevention. U. S.
“That coverage is rarely one hundred percent, but it’s something,” Link-Gelles said. have some coverage against infection and some coverage against your beloved’s infection that have no coverage at all.
Link-Gelles says this also means other people deserve to continue taking a layered approach to protect themselves, employing immediate testing, smart quality masks and ventilation as a comprehensive method, rather than relying on vaccines alone.
“This deserves to be one of the things in your toolbox to protect you and your circle of family,” he said. “Personally, my circle of relatives is up to date, but I think if we go to the airport tomorrow, we will wear our N95 [masks] because we will see elderly parents this weekend. And while of course we accept vaccines, and I’m not too worried about a mild infection in me or my healthy husband, we wouldn’t actually need to infect his grandmother.
Link-Gelles added that he expects vaccine coverage against the severe consequences of Covid-19, such as hospitalization and death, to be higher, but this information is still available.
The study, led by CDC scientists, was based on fitness records from more than 360,000 tests conducted at approximately 10,000 retail pharmacies between Sept. 14 and Nov. 11, a time when the BA. 4 and BA. 5 subvariants caused the peak of covid. . -19 infections in the United States. The study included other people over the age of 18 who had symptoms of covid-19 and were not immunocompromised.
The study looked at the effectiveness of boosters in two ways: The researchers calculated a price called absolute vaccine efficacy, which compared the risks of symptomatic infection in other people who received bivalent boosters with those who reported not being vaccinated. They also calculated the relative effectiveness of the vaccine, which looked at the risks of symptomatic infection in other people who received upgraded bivalent boosters compared with those who received two, three or four doses of the original single-strain vaccine.
Compared to unvaccinated people, older adults aged 18 to 49 who had gained bivalent boosters were 43% less likely to have health problems with Covid-19 infection. Older people, who tend to have weaker immune function, have less protection. People older than 50 to 64 were 28% less likely, and people 65 and older were 22% less likely to have health problems with COVID-19 than the unvaccinated group.
The relative efficacy of the vaccine showed the additional coverage that other people can expect, in addition to the coverage they had left over from previous vaccine doses. 30% coverage for other seniors ages 18 to 49, 31% additional coverage if they were between 50 and 64, and 28% additional coverage if they were 65 or older. At 3 months after their last booster, other people over 50 still had about 20% coverage against COVID-19 disease, according to CDC data. Therefore, overall, the updated reminders allowed them to achieve an effectiveness of around 50% against symptomatic infections.
If a user was more than 8 months away from their last dose of the vaccine, it was higher through boosters. But Link-Gelles said that at 8 months there was little coverage left from past injections unlike Omicron and its variants, meaning the vaccine’s effectiveness because this organization was likely close to its overall coverage opposed to infection.
People aged 18-49 years who were 8 months or older after their last dose of vaccine had 56% more coverage compared to Covid-19 infection with symptoms; Older adults ages 50 to 64 had an additional 48% coverage and adults 65 and older had an additional 43% coverage, the most sensitive of all that remained beyond vaccines.
John Moore, an immunologist and microbiologist at Weill Cornell Medicine, said it all boils down to the fact that boosters would likely reduce the risk of health problems by about 50 percent, and that coverage probably wouldn’t last.
“Having a booster will give you extra coverage compared to short-term infections, which we see with a booster, but it probably wouldn’t last long. It will be minimized and further reduced as the tougher variants spread,” Moore said. , who was not involved in the new investigation.
The picture of immunity in the United States is more complex than ever. To the CDC’s knowledge, about two-thirds of Americans have finished at least their first round of COVID-19 vaccines. And knowledge of blood tests shows that nearly all Americans have some immunity to the virus, infection, vaccination, or both.
A new preprint from Harvard and Yale researchers estimates that 94% of Americans have been infected with the virus that causes COVID-19 at least once, and 97% have been infected or vaccinated, expanding coverage against a new Omicron infection from an estimated 22% in December 2021 to 63% as of November 10, 2022. Public coverage of serious illnesses increased from around 61% in December 2021 to around 89%, on average, in November.
All of this means that the U. S. is not in the U. S. The U. S. is in a better position, at least defensively, than it has ever opposed the virus, which is not to say that the country simply can’t see a wave of Covid-19, especially if a new variant emerges that is very different from what we’ve seen, if immunity continues to wane, or if the habit adjusts dramatically.
El-CNN-Wire™
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