“First, we stratified patients based on their molecular signature as mild/moderate or severe COVID-19, and then we learned about metabolic rearrangement related to disease severity,” says the first examination Anoop Ambikan, Ph. D. Holder Anoop Ambikan. student in the Department of Laboratory Medicine, Karolinska Institutet.
The researchers used multi-omics, the simultaneous measurement of many biomolecular variables, allowing for a complete profile of human biology. Blood samples from COVID-19 patients at other stages of the disease were analyzed, several complex RNA research techniques, adding quantitative research. changes in immune cells called mononuclear phagocytes. This plays a vital role in the immune system’s ability to destroy the invading pathogen and facilitate healing and repair.
Specific metabolic processes with COVID-19 severity identified
A virus depends on host nutrients to reflect and reproduce. It alters the amount of metabolites through a metabolic network for its own benefit. On the other hand, the host counteracts the virus through an inflammatory immune response.
“Our knowledge recommends that in mild/moderate and severe cases of COVID-19, the main metabolic arrangements occur in white blood cells called monocytes, in the central metabolic pathway called the TCA cycle, which is the energy source for cells to carry out their certain metabolic reactions may be similar to the severity of the disease. ” explains the study’s lead author, Ujjwal Neogi, a researcher at the Department of Laboratory Medicine at Karolinska Institutet. He continues:
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