In a recent post on the medRxiv* pre-draw server, researchers investigated a potential relationship between vaccination against coronavirus disease 2019 (COVID-19) and sudden sensorineural hearing loss (SSNHL).
Several reports of SSNHL cases similar to COVID-19 vaccination have emerged from the pandemic. The European Database of Reports on Suspected Adverse Drug Reactions lists more than 1000 SSNHL reports similar to COVID-19 VACCINATION as of March 15, 2022. An examination in Israel reported that the threat of SSNHL increased particularly after vaccination with Pfizer’s BNT162b2 vaccine.
The combination of SSNHL with coronavirus 2 (SARS-CoV-2) infection of severe acute respiratory syndrome remains controversial. No obvious combination was found between COVID-19 and SSNHL, where no patients with SSNHL tested positive for SARS-CoV-2. However, some studies have described the occurrence of SSNHL following sars-CoV-2 infection.
In the provided study, researchers evaluated the associations of COVID-19 vaccination and SARS-CoV-2 infection with SSNHL. They tested the appearance of SSNHL in Finland between 1 January 2019 and 12 April 2022. A national sign containing information about birth, gender and non-public identity codes unique to all Finnish citizens were used to identify all people born or alive in the study.
People diagnosed with sudden hearing loss between 2015 and 2018 were excluded. Vaccination knowledge was received from the National Immunization Registry and infection knowledge from the National Infectious Diseases Registry. The first positive SARS-CoV-2 control result was used as the date of infection and recurrent infections were not considered as. The first occurrence of sudden idiopathic hearing loss after January 1, 2019 was considered an incident case of NHSS.
Vaccine prestige classified as “unvaccinated pre-epidemic”, “unvaccinated epidemic” and “vaccinated”. in addition, the vaccinated state was stratified into threat status number one (≤ 54 days) and secondary (≥ 55 days). Infectious prestige explained as inflamed or non-inflamed.
The prestige of the infection was not inflamed for the entire cohort before the COVID-19 pandemic. The inflamed state was stratified into periods of number one and secondary threat after infection. Using a Poisson regression model, the researchers calculated the adjusted rate of occurrence (aIRR) indices between vaccine exposure between states and states not vaccinated before the epidemic and between states of exposure to infection and state without inflammation.
Time-invariate covariates were sex, diabetes, number of chronic diseases, retirement home care, cardiovascular disease, number of number one care visits, assisted living, and other residential residences. The time-independent covariates were vaccine/infectious status, age teams, and calendar months. An herbal spline serves as used, taking into account nonlinear adjustments in the occurrence of NHSS consistent with the calendar month.
In the Finnish population, the monthly crude occurrence of SSNHL varied between 2016 and 2019, from 13 to 23, with 100,000 regular year-years (pyrs). After 2016, the lowest occurrence was in April (11/100,000 pyrs) and May. 2020 (12/100,000 pyrs) and the highest in February 2021 (27/100,000). After that, the effects consistent with the month were variable, similar to those prior to 2020. From January 2019 to before COVID-19, 1,216 subjects had an SSNHL with a crude occurrence of 18. 7 consistent with 100,000.
A sudden reduction in the occurrence of SSNHL in the initial phase of the pandemic (March 2020) was noted that reached pre-COVID-19 grades in late 2020. -2 vaccination schedule in early 2021. The uncooked occurrences of SSNHL, the number one threat consistent with the first dose of the Oxford mRNA-1273 ChAdOx1, BNT162b2 and Moderna vaccines were 24, 20. 9 and 16 consistent with 100,000, respectively.
The aIRRs were < 1, indicating the absence of a major threat from SSNHL after the first vaccination. The number one and momentary threat periods after the moment and the third dose were not particularly different from the unvaccinated period prior to COVID-19. In addition, the authors found no evidence that the threat of SSNHL is greater after SARS-CoV-2 infection. The aIRRs were 1. 3 and 1. 1 for the number one and momentary threat periods after infection, implying that the occurrence of SSNHL is not particularly different from the period without infection.
The study evaluated the relationship between SARS-CoV-2 vaccination and SSNHL infection, comparing the occurrence of post-vaccination SSNHL with this before the COVID-19 pandemic. In conclusion, there was no evidence of the alleged relationship of COVID-19 vaccination with SSNHL, and aIRRs were more commonly ≤ 1 the number one threat era after vaccination.
medRxiv publishes initial clinical reports that are not peer-reviewed and therefore should not be considered as conclusive clinical practices/health-related behaviors, nor treated as established information.
Written by
Tarun was founded in Hyderabad, India. He holds a master’s degree in Biotechnology from the University of Hyderabad and is passionate about clinical studies. She enjoys reading study articles and literature reviews and is passionate about writing.
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