Health care company Abbott has reshaped the check landscape in the United States. On August 27, 2020, the company announced the acquisition of FDA approval to distribute a new type of pioneering check: a check that will charge $5 each.
Trump’s management later said it would buy 150 million tests from Abbott, but by comparison, states have reported less than a million tests overall over the past six months.
Abbott control is a type of antigenic control. Compared to PCR control, it is faster, more convenient and less expensive. In addition, compared to antibody control, the use of antigen control may run into the virus in those that are carriers but show no symptoms; In addition, this is not limited to the appearance window.
Antibody pairs are the essential reagents for antigen control kits. High-quality antibody pairs can help specificity and sensitivity. Potentially, the sensitivity of antigenic control may simply correspond to the fair sensitivity of the PCR control.
However, for the progression of antigenic tests, scientists have recently faced a relationship with the most productive approach of the variety for an appropriate pattern for test progression. It is clear that the most productive pattern is the patient’s nasopharyngeal swab, but for biosecurity. reasons, it would possibly be difficult to access the patient’s patterns at the beginning of the discovery phase.
Therefore, most scientists use recombinant antigenic proteins added in samples to check development; however, this strategy is flawed because some of the recombinant proteins would possibly not constitute the most productive distribution of the virus. In addition, the lysis of swab samples does cause an unwanted breakage of proteins, which is the recombinant protein is not able to replicate. In short, recombinant protein is insufficient when antibody pairs are selected.
Two pairs of variable antibodies, recombinant proteins and an inactive virus, were tested. As shown in Figure 1 below, the sensitivities differ.
The most reliable way to compare an antigenic control is to use an inactive virus to control progression. For the progression of the IVD product, ACRO has prepared a series of high quality recombinant protein reagents, especially pairs of antibodies. were tested and shown using inactivated virus samples. The sensitivity of the ELISA sandwich can be as low as 12 pg/ml. The title, which was resolved by our LFA check, is as low as one hundred DICC50.
These antibodies have been for the detection of antigens using a double antibody sandwich.
>>> Viral Lysis Buffer is now available for progression of an antigen detection kit.
A 10-times serial dilution was performed for inactive virus patterns on a lysis pad (catalog number LY-13) from 105 DICC50 to 10 DICC50. Therefore, pairs of ACRO anti-nucleocapsid antibodies, one hundred ul of each pattern, were added to the evolved LFA control strip. The readings were taken within 15 minutes (clear line, waveline):
The verification was then repeated and the following effects were consistent, demonstrating reproducibility and pairs of high-quality ACRO anti-nucleocapsid antibodies.
ACROBiosystems is a leading manufacturer of recombinant proteins and other reagents essential for the progression of targeted therapies. The company uses an application-oriented progression strategy, with a specific focus on product design, quality control, and solution-based fixes. Our products and facilities allow anyone in the drug progression chart to have a more intuitive and optimized process.
In reaction to the coronavirus pandemic, ACROBiosystems has developed SARS-CoV-2 antigens specially designed and optimized for serological test kits, adding S1 antigen derived from Spike, RBD and nucleocapsid protein, which is provided to diagnostic companies in giant quantities.
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