While the effects of COVID-19 on the lungs and formula for breathing are known, a framework of developing studies suggests that the virus also affects the heart, with potentially lasting effects.
In a presentation at the annual meeting of the Biophysical Society, a foreign clinical organization on biophysics, Dr. Andrew Marks, chair of Columbia University’s Department of Physiology, and colleagues reported on adjustments in the core tissue of COVID-19 patients who had died from the disease, some of whom also had a history of problems at the center. The team conducted post-mortem examinations and discovered a variety of abnormalities, namely in the calcium of the center’s cells.
All muscles, adding those of the center, have calcium to contract. Muscle cells store calcium and open special channels within cells to release it when needed. In certain situations, such as central failure, the canal remains open in a desperate attempt for the central muscle to contract more actively. Calcium leakage eventually depletes calcium stores, weakening the muscle in the end.
“We discovered evidence in COVID-19 patient centers of abnormalities in the way calcium is managed,” Marks says. In fact, when it comes to their calcium systems, the core tissue of the other 10 people who died of COVID-19 looked a lot like that of other people with central failure.
Marks plans to further explore the heart changes that SARS-CoV-2 can cause by reading how the infection affects the centers of mice and hamsters. It is intended to measure changes in immune cells and any changes in the center as in animals while they are inflamed and after they have recovered to document any lingering effects.
“The data we provide shows that there are dramatic changes in the heart,” Marks says. “The exact cause and long-term consequences of these need to be further investigated. “
Previous studies have found a link between COVID-19 infections and center problems. A giant 2022 investigation of VA-formula patients, some of whom had recovered from COVID-19 and others who had never been diagnosed, showed that those who had had COVID-19 had higher rates of a number of core risks, adding abnormal central heartbeat, central attack, and stroke. Susan Cheng, chair of population sciences and women’s cardiovascular health at Cedars-Sinai, is reading about whether there are associations between central attack rates and COVID-19 outbreaks to better understand how the virus might affect.
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Initial evidence is also emerging that other people with high blood pressure would be at increased risk for heart problems when they contract COVID-19.
It’s not yet known what links viral infection to the center, but the framework’s immune formula is likely a major contributor. “It is well documented that with SARS-CoV-2, the framework responds with an inflammatory reaction that activates the immune formula in a very dramatic way,” says Marks. “In the center, it appears that the same inflammatory procedure activates pathways that can affect center function. “But more studies want to explain this procedure, says Dr. Brown. Mariell Jessup, lead scientist and physician with the American Heart Association. “If the speculation is that infection causes inflammation and inflammation precipitates more cardiovascular events, then how does it do it?”
It is also possible for viruses to infect and have negative effects on central cells. “We are still at the tip of the iceberg when it comes to understanding the health effect of COVID-19,” Cheng says.
Marks hopes to get some of those answers with the animal experiments he plans to conduct. “We hope to optimize animal style to better reflect what we think is in patients,” he says. Signal what happens in the center when the virus infects an animal. “
Ultimately, this wisdom will help better treat others who might be at higher risk for medical problems like COVID-19, which in turn can also reduce hospitalizations and deaths from the disease. Marks has also developed a potential drug that can treat calcium leakage if it proves to be a challenge with COVID-19; He is in a position and willing to see if his animal studies justify the experiments.
Until more definitive studies explain how the COVID-19 virus affects the center, Jessup says he would recommend his patients “control the things we know we control,” such as threat points that could put them in a top threat of disease from the center to begin with. with, such as obesity, high blood pressure and high cholesterol. And with more emerging knowledge, if other people get repeated COVID-19 infections, it’s probably also worth seeing your doctor to check your risk points for central disease.
“We spend a lot of time telling other people to get vaccinated,” he says. “For other people who have had COVID-19, we also want to make sure they know their center number and know their blood. “to save you from the central disease, so let’s do the things we know how to do. “