A large-scale global trial designed to test the theory that the widely used BCG vaccine may be an aid to COVID-19 will soon recruit fitness personnel and staff in the UK.
The University of Exeter is leading the trial in the UK, called “BCG Vaccination to Reduce the Impact of COVID-19 on Health Workers” (BRACE).
The BRACE trial is coordinated through the Murdoch Children’s Research Institute (MCRI) in Melbourne, Australia. The trial earned more than $10 million from the Bill and Melinda Gates Foundation to enable its global expansion. The Peter Sowerthrough Foundation helped fund exeter’s site.
The United Kingdom joins the examination centres in Australia, the Netherlands, Spain and Brazil in the largest test of its kind. Together, the test will recruit more than 10,000 fitness workers. Participants will get the BCG vaccine (currently given to more than one hundred million young children worldwide each year to protect against tuberculosis (TB)) or a placebo injection. In the UK, the BCG vaccination regimen was discontinued in 2005 due to low TB rates in the general population.
Professor John Campbell, of the Faculty of Medicine at the University of Exeter, is the leader of the BRACE study in the UK and said: “COVID-19 has killed more than one million people worldwide, with more than 33 million people contracting the disease, BCG has been shown to increase immunity widely , which would possibly be offering some shield in front of COVID-19. We are pleased to make a contribution to the large-scale foreign BRACE study, which seeks to find out if the BCG vaccine can also help protect those at risk of COVID-19. If this is the case, we can also save lives by providing or supplementing this vaccine easy to obtain and cost-effective.
Previous studies recommend that the Bacillus Calmette-Guerin (BCG) vaccine would possibly decrease susceptibility to a variety of viral infections, adding those of the new COVID-19-causing coronavirus. A review of the mechanism through which this can paints is a test component performed through BRACE researchers.
The BCG vaccine strengthens immunity through the “training” of the immune formula to respond to additional infections with greater intensity. Researchers hope that this advanced “innate immunity” will save a very important time to expand an effective vaccine opposed to COVID-19.
The BRACE trial first recruited care and fitness personnel in south-west England who can simply make a stopover at clinics in Exeter. The essay aims at these professionals because they paint in spaces highly exposed to COVID-19. The BCG vaccine reduces coronavirus infection or the severity of COVID-19 symptoms.
Professor Campbell added: ”People on the front line of COVID-19, adding physical care personnel and house staff, are especially vulnerable to coronavirus infection. So far, nursing home staff have been overlooked through maximum research. opportunity to provide forward-looking assistance to this vital organization of others who provide physical care to some of our most vulnerable citizens in vital network environments. I inspire care home staff to register to help us find out if the BCG vaccine can be a safe, widely available and cost-effective way to reduce the threat of COVID-19. “
In the UK, the trial will be conducted through the Exeter Clinical Trials Unit (CTU) and will be supported by the Clinical Research Centre funded through the National Institute of Health Research. Lynne Quinn, chief operating officer of Exeter CTU, said the trial was the first of All sought to recruit 1,000 participants to paint in nursing homes and other netpaintings fitness care facilities. She said: “The first recruiting wave will take place in and around Exeter, and we have interesting plans to expand to other sites in the UK, so we hope to develop our hiring staff at a later stage. “
Professor Nigel Curtis, global director of the BRACE trial at MCRI, said: “We are very pleased that the UK will join this foreign trial to help if we can reuse an existing safe vaccine to lessen the impact. COVID-19 on health painters, adding those who paint in nursing homes and those at risk. “
Participants will be asked to complete a daily symptom diary through an application, have a COVID-19 test when they have symptoms, complete questionnaires, and blood samples that will allow scientists to perceive how blood cells react to COVID-19 exposure. and other viruses, with and without the BCG vaccine.
Learn or sign up for the test at the University of Exeter
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