Police ordered one group near the Brandenburg Gate to disperse for flouting safety rules, then arrested 200 after rocks and bottles were thrown.
Protesters were closely packed in places, and sat together on the ground at one point.
A momently organization of about 30,000 people gathered peacefully nearby to listen to speeches.
Among those arrested was cookery author and conspiracy theorist Attila Hildmann, who had addressed crowds through a loudspeaker.
The demonstration west of the Victory Column Gate organized through the Stuttgart-based Querdenken 711 (or Lateral Thinking 711) movement. The organization has more than 16,000 followers on Facebook and communicates largely through the encrypted messaging service Telegram.
Kennedy told the crowd in the victory column that his uncle had to go to Berlin in 1963 to counter totalitarianism and that “today Berlin has returned to the lead against totalitarianism”, caution against a state of surveillance and the strength of 5G telephone networks.
Counter-managements opposed to the great march were also carried out, with about a hundred more people at a rally. “You’re walking with the Nazis and the fascists,” some participants shouted, according to RBB station.
The country was one of the most effective in enforcing the framework of response referred to as prevent, detect, contain and treat.
It has been particularly effective in keeping the death rate among the over 70s lower.
On Thursday, Chancellor Angela Merkel and the 16 federal states imposed a minimum fine of 50 euros (45 euros; 59 dollars) for not wearing a face mask on request. The ban on major public occasions has also been extended until next year.
Germany has recorded 242,000 infections, fewer than the other major European nations. Its figure of 9,297 deaths is considerably lower than the numbers in Russia, the UK, Spain, France and Italy, Johns Hopkins University research shows.