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It would possibly be imaginable to lessen the severity of COVID-19 symptoms with an affordable amino acid that can also open up new treatment functions for patients. GABA is an herbal molecule that is obtained without a prescription in many countries. Researchers have now used a mouse-style SARS-CoV-2 infection to show that the GABA remedy can reduce viral load, symptom severity, and mortality from COVID-19. This research team showed in the past that GABA can save you from death in a mouse-style coronavirus infection, which used a virus called MHV-1. When mice were fed GABA a few days after infection, or during the peak of infection, the remedy was effective. The researchers cautioned that since GABA works in the opposite way to two unrelated coronaviruses, it may also be useful as a general remedy for novel beta-coronaviruses and variants of SARS-CoV-2. The effects were reported in Frontiers in Immunology.
New variants of SARS-CoV-2 will continue to emerge, and the drugs and vaccines we are using recently may not be effective. New vaccines will also arrive more slowly than new variants, said study lead author Daniel L. Kaufman, a researcher and professor at the David Geffen School of Medicine at UCLA.
When the researchers decided that GABA could reduce the severity of symptoms when mice became inflamed with MHV-1, a mouse coronavirus, they tested it on a type of mouse with severe SARS-CoV-2-induced pneumonia. The untreated mice died. But when those mice were given GABA right after infection, or two days later, some symptoms were relieved and mortality decreased.
The treated mice also underwent biochemical changes in immune molecules, chemokines, and cytokines, which were linked to better outcomes for COVID-19 patients.
The study authors also hope that the anti-inflammatory nature of this remedy may help reduce problems, such as inflammation of the central nervous system, that are linked to the long duration of COVID.
More paints will be needed to verify that GABA is effective for COVID-19 patients, but it is solid at room temperature and affordable to manufacture, so it can be especially useful in spaces where health care can be difficult to access, the study leader noted. author, Daniel. L. Kaufman, researcher and professor at the David Geffen School of Medicine at UCLA.
While GABA and GABA receptors are considered to be part of the brain’s neurotransmitter system, immune cells are also known to express GABA receptors. Activation of GABA receptors on immune cells is known to be inhibited through inflammation. Treatment with GABA would possibly help relieve symptoms. of certain mouse models of autoimmune diseases such as type 1 diabetes, multiple sclerosis and rheumatoid arthritis.
The authors noted that clinical trials will be needed before GABA proves to be a reliable, COVID-19 treatment, and that others deserve not to consume it without a doctor’s direction and guidance. Taking GABA by mouth may pose certain health risks. , such as immune interference.
Sources: University of California, Los Angeles, Frontiers in Immunology