Coronavirus-19 disease (COVID-19) is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The long incubation era of this new virus, which is generally asymptomatic but contagious, is one of the main reasons for its immediate spread worldwide. Currently, there is no approved international remedy for COVID-19. As a result, clinical and clinical communities are running in combination to lessen the serious consequences of the epidemic. Research into emerging infectious diseases in the past has created valuable wisdom that is being harnessed for drug reuse and accelerated vaccine development. However, it is vital to generate wisdom about the mechanisms of SARS-CoV-2 infection and its effect on host immunity, to consult the design of specific COVID-19 treatments and vaccines suitable for mass vaccination. Nanoscale supply systems are expected to play a key role in the good fortune of these prophylactic and curative approaches. This review provides a review of sarS-CoV-2 pathogenesis and examines the immunomediated approaches that are being recently explored for COVID-19 remedies, with an emphasis on nanotechnology tools. This review provides a review of sarS-CoV-2 pathogenesis and examines the immunomediated approaches that are being recently explored for COVID-19 remedies, with an emphasis on nanotechnology tools.