A national study suggests that risk points for cardiovascular disease, such as age, smoking, and diabetes, not a pre-existing core disease, are the main drivers of death and poor outcomes for critically ill COVID-19 patients.
A team led by researchers at Michigan Medicine analyzed the outcomes of more than 5100 patients admitted to intensive care sets at 68 U. S. centers with severe COVID between March and June 2020. Of those patients, 1174 had pre-existing coronary artery disease, insufficiency of the congestive center disease, or atrial fibrillation.
The effects reveal that patients with cardiovascular disease had a nearly 30% higher mortality rate than severely ill COVID patients without the pre-existing condition. It is no longer statistically significant. The effects are published in Circulation: Cardiovascular Quality and Outcomes.
The fact that the relationship between cardiovascular disease and death was so drastically reduced when comorbidities were controlled for suggests that cardiovascular risk points, rather than pre-existing core disease, are the main participants in hospital death in patients with severe COVID-19. “
In total, 34. 6% of patients died within 28 days and only about 18% experienced a cardiovascular event, such as cardiac arrest or myocarditis. illness.
Cardiovascular disease is a common condition in patients suffering from severe COVID illness, given its prevalence in the elderly and related chronic inflammation. In the study, age, obesity and diabetes were much stronger predictors of COVID deaths.
Regardless of whether or not a patient had a pre-existing clinical disease, the researchers found that the presence of myocardial injury was linked to cardiovascular events and death. Higher levels of troponin, a protein that is released when the core muscle is damaged. Patients with the highest troponin measurements were nearly three times more likely to die than those without myocardial injury.
“While severe COVID patients generally showed symptoms of central injury, our findings reinforce COVID-19 as a multi-organ injury lung disease related to systemic inflammation,” Hayek said. 19 more likely reflects the severity of the disease and the strain it puts on all organs rather than the progression of new headaches or exacerbation of a pre-existing central disease. “
The findings deserve not to minimize the fact that cardiovascular disease patients are still in mortal danger due to COVID-19, as they have a higher burden of disease threat points, such as diabetes, high blood pressure and smoking, says co-first Alexi Vasbinder, Ph. D. , R. N. , a graduate intern in internal medicine.
“Lately we are conducting studies to better delineate the groups of COVID-19 patients at the highest risk of serious outcomes, such as those with complex central failure or coronary heart disease,” Vasbinder said.
Michigan Medicine – University of Michigan
Vasbinder, A. , et al. (2022) Relationship between pre-existing cardiovascular disease and death and cardiovascular outcomes in critically ill patients with COVID-19. Quality and cardiovascular outcomes of the circulación. doi. org/10. 1161/CIRCOUTCOMES. 122. 008942.
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