Researchers from the Federal University of Maranhao in Brazil have made a suggestion that Maranhao state is on track to obtain collective immunity against Coronavirus 2 of Severe Acute Respiratory Syndrome (SARS-CoV-2), the culprit agent of coronavirus disease. (COVID-19).
SARS-CoV-2 – Electronic micrograph with SARS-CoV-2 virus particle transmission, remote of a patient Captured symbol and color enhancement at NIAID Integrated Research Center (IRF) in Fort Detrick, Maryland Credit: NIAID
Alcione Miranda dos Santos and her colleagues claim that the estimated prevalence of detectable antibodies (seroprevalence) is the highest and closest to the reported collective immunity threshold to date. The infection mortality rate is also one of the lowest reported to date.
The seroprevalence of general antibodies opposed to SARS-CoV-2 reaches 40. 4%, which, according to the authors, is the first time that a prevalence rate of this diversity has been reported.
“Our knowledge recommends that collective immunity be received earlier than expected,” the team wrote.
You must have a preprinted edition of the article on the medRxiv server, while the article is peer-reviewed.
Since the onset of the COVID-19 epidemic in Wuhan, China, at the end of last year, Brazil has been one of the countries most seriously affected by the pandemic.
The first known case in the country on February 26, 2020. On 20 August, SARS-CoV-2 is believed to have inflamed another 3,501,975 people and caused 112,304 deaths, the highest number of COVID-19-related deaths in the world.
Brazil’s reaction to the pandemic has been controversial, capacity has been weak, and government uncertainty about social distancing measures has left the population with mixed messages.
Subsequently, social estating was never implemented enough to slow the spread of the disease and involve the pandemic.
Located in the northeastern region of Brazil, Maranhao is one of the states where SARS-CoV-2 temporarily spread at the beginning of the pandemic. The first case was reported on March 20, and as of August 20, the death toll for COVID-19 had reached 3,315.
The authors say the mortality rate peaked in May and began to decline thereafter.
The threshold for collective immunity is still under discussion, and some reports suggest that 60-70% of the population has become inflamed and others estimate figures as low as 10-20%.
The authors state that few population studies have been conducted for Brazil on the prevalence of SARS-CoV-2 and that they have basically used lateral immunological doses with digital puncture tests, which can roll back false negative effects and lead to an underestimation of the actual infection rate, the authors warn
“As a result, population-based surveys, more delicate diagnostic tests, are warranted,” the team said.
What is the existing study?
Miranda dos Santos and her colleagues conducted a population survey of 3156 participants living in Maranhao state between July 27 and August 8 and estimated the overall seroprevalence of SARS-CoV-2 in electrochemistry immunological serum tests.
Researchers report that the seroprevalence of general antibodies opposed to SARS-CoV-2 is 40. 4%.
“As far as we know, this is the first population based on reporting a prevalence rate within this range, for a region as giant as Italy,” the team wrote.
Adherence to non-pharmaceutical interventions was greater at the beginning of the pandemic than in the last month; respect for social distance increased from 52. 7% at the start of the pandemic to 37. 4% last month, while mask compliance increased from 61. 4% to 55. 5%.
SARS-CoV-2 infection rates decreased particularly in the following month among mask wearers and those who have been away from others for at least 15 m, who did not adhere to those measures.
The overall infection mortality rate (IFR) is 0. 17%, but higher for men and the elderly.
“The IFR in Maranhao is one of the lowest on record to date,” he wrote.
The team claims that the COVID-19 pandemic peaked in the state between May 17 and 23, 2020, and that mortality has since declined.
Economic activity has slowly expanded since many of the mitigation measures began to relax. Nearly 3 months after social estating measures were relaxed, the number of reported deaths remains low, despite increased network mobility.
The authors state that, as far as they know, the seroprevalence of SARS-CoV-2 estimated in this exam is the highest and closest to the reported threshold of collective immunity to date.
“While there are still doubts about what this threshold is, our knowledge recommends that it be at least 40%, and it seems to be as low as 20% as some have recommended,” they write.
The team says maranhao’s effects are more than part of the threshold of collective immunity.
“Combined with knowledge, our knowledge recommends that collective immunity be received earlier than expected,” the team concluded.
To date, Brazil reports more than 3. 95 million SARS-CoV-2 infections and more than 122,000 COVID-related deaths.
medRxiv publishes initial clinical reports that are not peer-reviewed and are therefore not considered conclusive, clinical practices/health-related behaviors, nor are they treated as established information.
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Sally holds a bachelor’s degree in biomedical sciences (B. Sc. ). He specializes in reviewing and synthesizing the latest discoveries in all covered medical spaces in major world-renowned, high-impact foreign medical journals, foreign press conferences, and newsletters from government agencies and regulators. At News-Medical, Sally generates news, articles about life sciences, and interview coverage.
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