The Oswaldo Cruz Foundation (Fiocruz) will participate in a phase 3 study abroad of the drug Molnupiravir, manufactured by the pharmaceutical company MSD. The aim is to test its effectiveness in preventing the spread and transmission of COVID-19 among other people exposed to the coronavirus. The announcement was made on Wednesday, October 6 through Fiocruz.
The search, which is scheduled to begin next week, will be carried out in seven centers in Brazil, two of which depend on Fiocruz, in the states of Mato Grosso do Sul and Rio de Janeiro. Researchers Julio Croda and Margareth Dalcolmo will work as coordinators.
The drug serves to block viral replication and can be active in several RNA viruses, in addition to SARS-CoV-2, which causes COVID-19. To test the effectiveness of molnupiravir as post-exposure prophylaxis, scientists will test Americans who have recently been exposed to the virus — other people who live with people who have tested positive for COVID-19 in the past 72 hours and who have at least one symptom similar to the disease.
Treatment involves giving the drug orally twice a day for five consecutive days. The duration will be six months.
Molnupiravir is being developed through MSD in collaboration with Ridgeback Biotherapeutics. Recently, MSD published interim phase 3 effects of another study, in which Molnupiravir was used as a remedy for the first five days of symptoms and showed approximately 50% relief in the threat of hospitalization or death in non-hospitalized adults with mild to moderate symptoms. COVID 19.
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