The results, which seem in cells today, recommend that the instances of 19 years and mortality rates in the United States in the United States will be superior to what would have been otherwise. The investigation recommends that the variant, which has been detectable in a proportion of samples SARS-COV-2, is 40 to 50% more transmissible than the SARS-COV-2 lines than in the dominant past. Other studies have discovered evidence that variant B. 1. 1. 7 would be about 50% more likely to cause a fatal COVID-19.
“B. 1. 1. 7 It has temporarily became the dominant SARS-COV-2 variant in the United Kingdom and other countries after its appearance at the end of last year, and the United States is now in a trajectory,” said the author examined, Kristian Andersen, PHD, professor of the studies of the Department of Immunology and Microbiology of Microbiology in the investigation of the microbiology of the scripts and the director Infectious genomic of scripps studies. “We want a rapid and decisive action to minimize the morbidity and mortality of COVVI-19”.
In addition to Andersen, the other eldest was William Lee, PHD, Vice President of Sciences of Helix, who provides COVI-19 PCR tests to PCR to the organizations of the United States. The exam was also written through Nicole Washington, PHD, director of associated studies in Helix, and Karthik Gangovarapu of the Andersen laboratory.
“B. 1. 1. 7 It has a duplication rate of just over a week and a higher transmission rate from 40 to 50%, which means that it can have a significant effect on public health,” Lee explains. “It is essential that we continue to monitor the spread of this variant and other emerging variants, however, our existing surveillance point is insufficient and is delaying that of other countries. We want a national genomic surveillance program of SARS-COV-2 to solve this problem. “
The variant B. 1. 1. 7 emerged in southern England last year and since the dominant variant in the United Kingdom in December, Andersen’s team in Scripps Research with colleagues from the University of California, San Diego, showed the first evidence of the variant in California.
A domination scheme
The variant B. 1. 1. 7 includes several mutations, many of which are in the gene that encodes the protein of the viral complex. These mutations accumulate the ability of the point to be linked to the Ace2 receptor in human cells. Although there is no evidence that the variant B. 1. 1. 7 can escape the COVVI-19 vaccines, public aptitude officials are concerned that their maximum propagation rate significantly aggravates the pandemic before vaccines can finish it.
Standard swab tests for coronavirus genetic sequences separated in 3 sites in the viral genome; The variant B. 1. 1. 7, due to its mutations, seems positive for two of those sites, but negative for the third site, which is in the image of the virus gene.
The new investigation of around 500,000 verification effects of the propeller since July 2020 revealed that these two out of every 3 models, known as the objective failure of the S, or SGTF, have constantly apparently apparent at low frequency (0. 2%) in mid -October. In the third week of February, it had reached a frequency of 10. 6% and was detected in patients from another 25 US states and territories.
The SGTF diagram can occur with other SARS-COV-2 variants that have mutations in specific genes, however, researchers discovered through the sequencing of the SGTF pattern that had from December to February, 662 of the 986 patterns (67%) contained variants B. 1. 1. 7. This suggests that the SGTF style in the swab tests can provide an immediate indication that is approximate of prevalence B. 1. 1. 7.
The variant has entered the field
The investigation also indicated that B. 1. 1. 7 since December has represented an immediate proportion of the SGTF effects, for example, reaching 95% in California to mid -January. In addition to the instances 659 B. 1. 1. 7 that detected the SGTF method, the researchers discovered another 3 instances of variant B. 1. 1. 7 Among the samples collected as components of the SARS-COV-2 genomic monitoring efforts not biased in California.
The 662 instances of B. 1. 1. 7 sequenced in the exam obtained here from samples collected in 10 US states, researchers point out that other verification laboratories that cover a general of 33 US states and territories have now informed the CDC at least one B. 1. 1. 7 case.
The investigation of the researchers of the circle of relatives type of sequences detected B. 1. 1. 7 shows that the variant has been brought in the United States several times from at least at the end of November 2020, specifically in California and Florida, and in periods that coincide with a building on the trip, adding the Thanksgiving week.
Scientists also discovered that the variant, in general, is to extend 40 to 50% faster than the Sars-Cov-2 variants that in the past dominated. They estimated that in the first week of February 2021, B. 1. 1 represented approximately 4. 3% of COVID-19 instances in the United States, adding 4. 2% of the instances in California and around 11. 5% of cases in Florida.
STUDY WAS PROVIDED THRUH US CENTERS FOR DIEW Health (UL1TR002550), The Innovative), The National Institute of Health (UL1TR002550), The Innovative), the National Institutes of Health (UL1TR002550), the innovative), the National Institutes of Health (UL1TR002550), the Genomic Institute and the new borders in the research fund provided through the Canadian Institute Health
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