AstraZeneca (AZN. L) has suspended human trials of a COVID-19 vaccine it has developed in partnership with the University of Oxford.
StatNews, a physician specializing in the United States, first reported Tuesday night that AstraZeneca had suspended a giant phase 3 test of AZD1222, an experimental vaccine formerly known as ChAdOx1 nCoV-19.
A spokesperson for AstraZeneca showed Yahoo Finance UK that the trial stopped after the discovery of an “unexplained disease” in a patient.
“As a component of the ongoing global randomized and controlled trials of the Oxford coronavirus vaccine, our popular review procedure was initiated and we voluntarily discontinued vaccination to allow for an independent review of protection data,” the spokesperson said.
“This is a regimen action that will have to happen whenever there is a potentially unexplained disease in one of the trials, while being investigated, making sure to maintain the integrity of the trials.
“In giant trials, diseases happen by chance, but they want to be analyzed independently to determine this carefully. “
Independent review is expected to take days and, if the disease is similar to the vaccine, trials will be restarted.
Shares in AstraZeneca fell more than 2. 5% at the start of trading in London, before cutting some losses.
The vaccine evolved in collaboration with the University of Oxford and is one of the most widely observed prospective COVID-19 vaccines in the world. Europe had already signed an agreement with AstraZeneca to produce 400 million doses of the vaccine in anticipation of a successful trial, while the United States had ordered 300 million doses.
Another 30,000 people in Brazil, the United Kingdom, the United States and South Africa are currently participating in drug trials.
A spokesman for AstraZeneca gave the main points of what in particular triggered the pause. StateNews reported that it had been triggered through “a suspected serious adverse reaction in a player in the UK”.
Dr. Adam Barker and Dr. Tara Raveendran, fitness analysts at swapping company Shore Capital, cited reports suggesting that the adverse effect could simply be transverse myelitis (MT), which is an inflammation of the spinal cord.
Dr. Barker and Dr. Raveendran stated that more main points were needed in the rehearsal break to draw definitive conclusions.
“Adverse events are not unusual in clinical studies and may have nothing to do with the vaccine (the maximum is not), but the most (if not the only) thing that can be done in such cases is to temporarily suspend the vaccine. study. and investigate what happened, ”the couple wrote in a note Wednesday morning.
The vaccine trial is scheduled to end in November, but Dr. Barker and Dr. Ravefinishran said the break would likely delay that schedule.
AstraZeneca spokesman said: “We are running to speed up the review of the singles occasion in order to minimize any possible effect on the trial schedule. We are committed to ensuring the protection of our participants and the highest criteria of conduct in our tests. »
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