A study in Japan shows that the antibody reaction to the Modern COVID-19 mRNA vaccine does not vary depending on the time of day the dose was received.
Many physiological and behavioral functions, in addition to the immune system, exhibit circadian rhythms. Several studies have investigated whether the immune reaction to COVID-19 vaccines varies depending on the time of day the dose is received, but the effects count according to the type of vaccine, age, and sex of the participants. Now, a study by scientists at Hokkaido University and colleagues in Japan found no relationship between the anti-frame reaction to the COVID-19 vaccine and the time of day of vaccination. The final vaccine optimization consultant. The findings were published in the Journal of Biological Rhythms.
The researchers recruited participants in their study from workers and academics at Hokkaido University who had obtained their first dose of the mRNA-1273 (Moderna) vaccine two to four weeks earlier. Those who in the past had become inflamed with COVID-19 were excluded. The organization of the study did not come with shift workers, a difference between this study and some previous studies of fitness workers.
The team collected demographic information about the final organization of 332 Japanese participants and took blood samples to measure antibody titers opposed to SARS-CoV-2. They then performed statistical analyses to determine if there were associations between the time of day the participants received their vaccine dose, any of the demographic characteristics, and the immune response.
“Our analyses did not discover a significant arrangement between the timing of vaccination and the concentration of antibodies against SARS-CoV-2, but we found that antibody titers decreased in participants aged 50 to 64 years, which is consistent with previous studies,” says Hokkaido University. . physiologist Dr. Yujiro Yamanaka, specialized in chronobiology.
Conflicting effects between studies can be explained simply through a variety of points, adding differences in sex, age, physical activity and herbal immune system, type of vaccine received, number of days after vaccination, and differences in vaccine dose. perceive whether other points such as race play a role.
The limitations of our ability to definitively rule out the option of circadian rhythms influencing the reaction of antibodies to vaccination. Larger randomised studies are needed to more conclusively consult vaccination methods for a time-of-day variable. “
Hokkaido University
Yamanaka, Y. , et al. (2022) Time of day of vaccination is related to SARS-CoV-2 antibody titer after the first dose of mRNA of the COVID-19 vaccine. Rhythms magazine biologiques. doi. org/10. 1177/07487304221124661.
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