A one-year-old baby who died of Covid-19 had a concentration of the virus in only a small component of the brain, suggesting it possibly would have a limited ability to reproduce there, according to Brazilian researchers.
But it can still cause an infection and cause an exaggerated immune reaction that would damage brain tissue, according to the study, led by neuroscientist Stevens Hostage of the Federal University of Rio de Janeiro.
The researchers concluded that the coronavirus “does not spread well in the brain,” in an article that was not peer-reviewed and published on the preprint server bioRxiv. org on Monday.
Children are less likely to become inflame with the virus or develop severe symptoms than adults; it’s still unclear how it affects them.
However, shortly after the first strain of the new coronavirus was identified, Chinese doctors discovered that this could seriously make some young people seriously ill.
The first case of a child was shown on January 20 in Wuhan and on February 2, more than 700 children were treated at the hospital for the disease throughout China, according to an examination by Jiao Tong University in Shanghai. The youngest of only 55 days of age.
Although symptoms in young children are sometimes mild, in China, about 10% of infants under 12 months of age who are inflamed with Covid-19 are seriously ill or have died from the disease.
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In the case of the one-year-old, The Hostage team discovered the most powerful viral presence in the choroid plexus: cells in the middle of the brain that produce a clear fluid in their tissues.
It has not been detected anywhere else in the brain, in a state of innuendo, indicating limited reproductive capacity, according to the newspaper.
However, Covid-19 will be associated with a number of neurological symptoms, experienced in approximately 30-60% of inflamed patients, such as loss of smell or taste, a burning or tingling sensation and a “non-ordinary state of consciousness”.
According to two weeks in March and April, the stroke rate also increased seven-fold among patients under the age of 50 in New York City.
Researchers who wrote in The Lancet Neurology this month said this was “probably similar to the presence of Sars-CoV-2 in those young patients,” the so-called coronavirus clinic.
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To determine their observations, the Hostage team challenged an organization of artificially cultured neural stem cells, or a neuroosphere, with the virus and discovered that the viral strain can infect brain cells, but may be reflected after entering.
“Our knowledge again concludes that the human brain is a snill for Sars-CoV-2,” they said.
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French in Paris reported the world’s first case of a baby inflamed with the virus in the womb in July.
The newborn suffered many neurological symptoms within 3 days of birth, adding muscle tension and spasms. The baby recovered and was discharged from the hospital 18 days later.
Hostage and his colleagues claimed that in the case of the one-year-old, if the infection gave the impression that it was limited to the cells where the liquid was generated, it could also have broken down a barrier regulating the exchange of matter inside. Brain.
They said this would mean that immune cells or signaling proteins, such as cytokines, could have invaded the central nervous system, “causing neuronal damage in the young brain. “
But the Brazilian team warned that an unusually high viral load may be something in their conclusions.
There is still little direct evidence of the effect of coronavirus on the brain. Researchers at Yale School of Medicine in Connecticut previously discovered that the virus can invade and reproduce in brain cells, while other studies have shown negative results.
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This article was first published in the South China Morning Post.